Cyclops

The Cyclops is a mythological creature, usually humanoid in form, that only has one eye. It can also be the name of any similar creature that only has one eye.

Mainstream Smurfs Media
In the cartoon show episode "The Smurfs Odyssey", the time-lost Smurfs met Loomis, the cyclops they found on the island where the magic shield for dealing with the Gorgon sisters is kept, who apparently is more afraid of the Smurfs and Hermes than they are of him.

In the comic book story "Sagratamabarb", a monkey-like being with only one eye called Tortorus was summoned by Gargamel to deal with the two horned demons that his cousin returned from hell with.