Acne

Acne is a medical condition in which a person breaks out with pimples on their skin. This normally first appears when the person enters adolescence, and usually goes away when the person enters early adulthood, although for some people the condition may last much longer.

Empath: The Luckiest Smurf stories
In the EMPATH: The Luckiest Smurf story series, acne is hardly considered a problem for the Smurfs since it only appears around the latter end of their childhood years and disappears when the Smurf enters early adulthood at 100 years of age, and also very few Smurfs even develop this condition.