Rome

Rome is a city in the European country of Italy that is considered its capital. In the ancient world it was successively the capital city of the Roman Kingdom, the Roman Republic and the Roman Empire, and is regarded as one of the birthplaces of Western civilization. Since the 1st century AD, Rome has been considered the seat of the Papacy and in the 8th century it became the capital of the Papal States, which lasted until 1870.

Mainstream Smurfs Media
In the Smurfs cartoon show as well as in The Lost Year period of the EMPATH: The Luckiest Smurf story series, the time-traveling Smurfs had adventures within or around the location of that city.