Surgery

Surgery is a medical procedure in which a patient is physically opened and operated upon by a physician with a staff of nurses or medical assistants on hand.

Mainstream Smurfs Media
As far as is known, the only known time that surgery was performed on a Smurf in mainstream Smurfs media was when Vanity suffered a broken toe in "Jokey's Funny Bone," with Papa Smurf performing the procedure by himself.

Empath: The Luckiest Smurf stories
In the EMPATH: The Luckiest Smurf story series, surgeries are mostly performed by Papa Smurf, with Dabbler assisting and then later taking over as the main surgeon. As far as known surgeries, Empath had a broken rib extracted during one of his visits to the Smurf Village, while Sickly had suffered "appendismurfus" about a few years after Empath had returned home for good from Psychelia.

Hero: The Guardian Smurf stories
In the HERO: The Guardian Smurf story series, chest augmentation surgery was performed on Wonder Smurfette by Papa Smurf and Doctor.