Transgenderism

Transgenderism is a prejudiced attitude toward transgendered people that is similar to sexism. It is a topic currently dealt with in today's society as people are learning how to accept people who are considered transgender (or "trans" for short).

Empath: The Luckiest Smurf stories
While transgenderism per se doesn't yet appear in any of the stories in the EMPATH: The Luckiest Smurf series, Duncan McSmurf does deal with his own feelings about being around Hogatha the witch when she was masquerading as a male Smurf, as does Smurfette.